精东影业

鈥奍n Maloney Hall earlier this year, a breast pump sat on a table, chugging like a metronome as it propelled formula through a baby bottle and into a glass beaker. After a minute, Britt Pados 鈥�03, an assistant professor at the Connell School of Nursing, recorded the amount of formula in the beaker, poured it back into the bottle, screwed a new silicone nipple into place, and restarted the machine.

For hours, as the timer beeped at sixty-second intervals, Pados recorded the rate at which formula flowed through various brands of bottle nipples. In jeans and a blazer, with an Apple watch on her wrist, Pados screwed and unscrewed plastic ring after plastic ring. It鈥檚 far from glamorous, but Pados鈥檚 work is helping to improve the artificial nipples used by millions of babies every day in hospitals and homes across the world.

It turns out that there are no objective standards for bottle nipples. Their flow rates vary wildly, and their marketing claims can be confusing to the point of being meaningless. That matters because specialists and researchers like Pados believe that nipple-flow rates鈥攍iterally, the rate at which nourishing fluid enters a baby鈥檚 mouth鈥攃an contribute to infant feeding problems. That鈥檚 especially concerning at a time when increasing numbers of parents are reporting such problems. The National Institutes of Health estimates that as many as one in four infants and toddlers are affected by feeding struggles.

Problems with feeding can pose health risks for babies and be a major source of anxiety for parents. Of the many things that expectant parents lose sleep over, their newborn鈥檚 ability to feed聽 is rarely on the list. Drinking formula or breast milk seems like something that will just happen organically. When it doesn鈥檛, it can feel like failing Parenting 101. 鈥淔eeding is a big part of establishing a bond with a baby,鈥� Pados said. 鈥淲hen that鈥檚 not going well, that鈥檚 really stressful, because they need to eat to live.鈥� One study likened parental reactions to their preemies鈥� feeding issues to post-traumatic stress disorder.

Pados鈥檚 work is changing the way that hospitals, parents, and specialists across the country select bottle nipples. But nipple-flow rates are just one of the factors that can contribute to infant feeding problems. Pados has also created assessment tools that are helping parents and pediatricians better identify and treat babies suffering from problems that range from long-term refusal of certain foods to inadequate nutrition during critical periods of brain development. And sometimes, at night, Pados will find herself responding to emails from desperate parents looking for help with feeding problems. She knows firsthand just what they are going through.

Growing up in Texas and Connecticut, Pados loved to hear her grandmother, a pediatric nurse, tell stories about the children she cared for. 鈥淚 knew pretty early on that I wanted to pursue a career related to the health care of children,鈥� Pados said. That led her to 精东影业鈥檚 undergraduate nursing program, during which she spent time in a neonatal intensive care unit, or NICU.聽 She fell in love with the intensity and focus of the NICU environment and, after eventually earning a master鈥檚 degree in nursing from the University of Pennsylvania, Pados became a neonatal nurse at Beth Israel Deaconess Medical Center in Boston and then a nurse practitioner at Morgan Stanley Children鈥檚 Hospital of New York-Presbyterian.聽

She worked with infants being treated for heart problems. It amazed her whenever parents would tell her that the most difficult part of the ordeal was not the cardiac surgery itself, but the weeks their infant would spend in the NICU afterward while learning to feed properly. 鈥淚 think parents can say, It鈥檚 not my job to do heart surgery. It鈥檚 not my job to manage medications,鈥� she said. 鈥淏ut being unable to feed your baby can feel like a personal failure.鈥�

鈥奍n the Maloney Hall testing room, boxes of bottle nipples were stacked on the floor and dozens of nipples in purple, blue, and orange rings awaited testing. This batch had come from Australia, the result of a research collaboration between Pados and a speech pathologist in that country. Over two days of testing in January, Pados and Rebecca Hill, a Ph.D. student in the Connell School of Nursing, measured their flow rates. Differences among the nipples were glaring enough to be apparent to the naked eye: Some emitted tiny drips into the beaker; others, significant drops.

A nipple鈥檚 flow rate can be crucial, because the mechanics of swallowing formula or breast milk are anything but simple. In many ways, feeding is the CrossFit of infancy. 鈥淚t鈥檚 the most physically strenuous and complex thing we ask them to do,鈥� Pados said. Every swallow requires a baby to hold his or her breath for around a second. 鈥淔or babies who are premature or have respiratory or cardiac issues, we鈥檙e asking them to suck, swallow, suck, swallow, so that they鈥檙e interrupting their breathing a lot,鈥� Pados said.

A couple of decades ago, she said, medical personnel interpreted preemies鈥� discomfort during feeding as fatigue. If milk came out of the bottle faster, they reasoned, the feeding would go faster and be easier on the baby. 鈥淲hat we didn鈥檛 know at the time was that the reason they were getting tired was because they were having to hold their breath so much,鈥� Pados said. 鈥淎 lot of these babies can鈥檛 hold their breath that much without becoming distressed. If we slow down the flow rate, it allows them to breathe more. It slows down the pace of the feeding.鈥�

When liquid exits a nipple too rapidly, she said, it can cause coughing or choking. Imagine running on a treadmill while trying to drink water being squirted into your mouth from a bottle. You鈥檇 hold your breath long enough to swallow but would end up gagging if the timing or volume of liquid wasn鈥檛 what you expected. Many newborns cope with a similar situation every time they eat, said Kayla Hernandez, a speech-language pathologist at Boston Children鈥檚 Hospital who works each week with up to forty children鈥攆rom birth through age six鈥攚ith eating disorders. It can be overwhelming and stressful and cause babies to not want to eat, and that can lead to feeding disorders. In extreme cases, she said, some children refuse all food and liquids, and need feeding tubes to survive.

For Shannon Goldwater, feeding issues of multiple forms surfaced after her triplets were born prematurely in 2002. Each of Goldwater鈥檚 babies weighed only a little more than a pound at birth, and spent four months in a NICU in Scottsdale, Arizona. At age 17, one of her sons still needs a feeding tube to meet basic nutritional needs. And because of a long-undiagnosed throat condition, her daughter refused liquids for more than a year and required frequent intravenous hydration.

Ideally, treatment for children such as Goldwater鈥檚 triplets would come from a team of medical specialists, including psychologists, speech-language pathologists, and nutritionists. Yet, a 2010 study in the journal Nutrition in Clinical Practice found that very few medical centers offer such interdisciplinary clinics, which can result in difficulties coordinating care and 鈥渟uboptimal treatment outcomes.鈥� What鈥檚 more, a 2015 study of family medicine, internal medicine, and pediatrics residency programs, published in the International Journal of Eating Disorders, reported that fewer than 10 percent included specific training on eating disorders.

With these problems in mind, Pados, Jinhee Park鈥攁n assistant professor in the Connell School of Nursing鈥攁nd a team of researchers from UNC developed five assessment tools to help parents and caregivers pinpoint feeding issues early.

The assessment tools (available at feedingflock.com) have begun to make a difference. So far, more than 4,000 people鈥攎ostly medical professionals, but also parents鈥攈ave requested access to them, Pados said, and they鈥檙e being used in inpatient and outpatient feeding clinics, neurodevelopmental follow-up clinics, and pediatric primary care.

Pados鈥檚 work on nipple-flow rates, meanwhile, has caused hospitals and baby feeding equipment manufacturers to take notice. Kayla Hernandez at Children鈥檚 Hospital said that 鈥渨ith Britt鈥檚 work, we鈥檝e been able to identify which of the slow-flow nipples are actually the slowest and therefore potentially the best fit for our young infants.鈥� Other hospitals have also made changes. In response to Pados鈥檚 research showing that the widely used 鈥淪imilac Premature鈥濃�攌nown as the 鈥渞ed nipple鈥� for its distinctive color鈥攚as very fast, many hospitals no longer stock that nipple for use in the NICU. Others have switched to Dr. Brown鈥檚 products instead of the disposable nipples provided by Enfamil and Similac. Enfamil recently created the new Enfamil Extra Slow Flow after hospitals requested聽 a slower-flow nipple than the products the company had historically offered.

Pados has also corresponded with the biomechanics expert Tommy Cunningham, COO and cofounder of Atlanta-based NFANT Labs, a medical device and digital health company working to improve the standard of care in infant feeding by providing objective, evidence-based medical products and services. When Cunningham鈥檚 company asked nurses and clinicians on the front lines of infant feeding in the NICU what they wanted in a feeding system, 鈥渙ne of the biggest frustrations we heard from them was the lack of reliability and consistency in flow rates from Enfamil and Similac nipples,鈥� he said. NICU staff members reported problems ranging from 鈥渟ometimes there is no hole鈥� to 鈥渢he flow can be so fast I was drowning my patient.鈥�

Ultimately, Pados would like to see all baby feeding equipment manufacturers following NFANT鈥檚 lead in conducting rigorous, science-based clinical testing of nipple-flow rates and other feeding systems鈥攁nd disseminating the resulting data. 鈥淲hat I try to do is give people information to make decisions,鈥� she said. 鈥淚t鈥檚 all about finding a balance between what鈥檚 safe for the baby and what鈥檚 efficient for the baby.鈥�

For her part, Goldwater is grateful that all of these issues are finally getting long-needed attention. The challenges her preemie triplets faced with feeding were profound enough that she went on to cofound Feeding Matters, an organization that works to raise awareness of such problems. The stakes, she said, are high for many parents and infants, 鈥渨hich is why we鈥檙e so thankful for practitioners like Britt who are really making a difference, so kids like mine don鈥檛 spend years and years suffering.鈥� 鈼�

Deborah Halber is a freelance journalist who often writes about聽science. Her work has appeared in The Boston Globe, MIT Technology Review, and Boston magazine.